About this trial
This study investigates the impact of ∆9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on recognition memory in healthy, regular cannabis users. Participants complete the same recognition memory task after self-administering one of two different strains of cannabis flower one day and while not intoxicated another day. Event-related potentials (ERPs) are measured via electroencephalogram (EEG) during the recognition memory task. Blood is collected to quantify THC and CBD exposure. Participants also complete self-report measures of medical history, sleep quality, subjective cognitive function, physical activity, psychological functioning, substance use, and acute drug effects.
Eligibility criteria
Qualifiers
Must be between the ages of 21 and 40 and provide informed consent;
Must be right-handed (Laterality Quotient > 60 on Edinburgh Handedness Inventory - Short Form136);
Must use cannabis at least 4 days during the month;
Must be a cannabis user for at least a year;
Disqualifiers
None
Trial design
Treatments tested in this trial
- Cannabis (smoked flower)
Treatment groups
Sponsors and collaborators
L. Cinnamon Bidwell
Lead sponsor
University of Colorado, Boulder
Sponsor institution
National Institute on Drug Abuse (NIDA)
Collaborator