About this trial
The goal of this observational study is to develop novel methods for integrating multimodal data streams with invasive neural recordings to study autobiographical memory (AM) formation in individuals with implanted neurostimulation devices (e.g., NeuroPace RNS) for epilepsy treatment. The main questions it aims to answer are:
How does the brain encode and retrieve real-world autobiographical memories? Can multimodal data integration enhance our understanding of memory-related cognitive and neural mechanisms?
Participants will:
* Use a smartphone-based recording application (CAPTURE app) to collect real-world data. * Have their wearable sensor data (e.g., audio-visual, accelerometry, GPS, autonomic physiology, eye tracking) synchronized with invasive neural recordings.
Researchers will analyze these multimodal data streams to develop new analytic approaches for studying memory formation in naturalistic settings, with the long-term goal of informing neuromodulation-based memory enhancement treatments for individuals with memory disorders.
Eligibility criteria
Qualifiers
18 years of age or older
healthy to minor cognitive impairment
Disqualifiers
younger than 18 years of age
more than minor cognitive impairment
Trial design
Treatments tested in this trial
- Free and Cued Recall Memory. Temporal Sequence and Spatial Memory
Treatment groups
Sponsors and collaborators
University of Utah
Lead sponsor
National Institutes of Health (NIH)
Collaborator
National Institute of Mental Health (NIMH)
Collaborator
University of California, San Diego
Collaborator
University of California, Los Angeles
Collaborator