Capturing MultiORgan Effects of COVID-19
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-100
SponsorUniversity of Oxford
About this trial
The C-MORE study is prospective observational holistic longitudinal study which will characterise the prevalence of multi-organ injury among COVID-19 survivors post hospital discharge and assess its effects on quality of life, exercise tolerance and mental health.
Eligibility criteria
Qualifiers
Participant is willing and able to give informed consent for participation in the study.
Male or Female, aged 18 years or above.
Diagnosis of COVID-19 infection confirmed by detection of viral nucleic acid on reverse-transcription Polymerase Chain Reaction (RT-PCR).
Infection should be of moderate to severe intensity (i.e, patients with clinical signs of pneumonia such as respiratory rate > 30 breaths/min; or severe respiratory distress; or SpO2 < 90% (on room air) and admission for >48 hours.
Disqualifiers
Contraindication to MRI e.g. pregnancy, pacemaker, ferromagnetic implant, shrapnel injury, severe claustrophobia, inability to lie flat.
Any other significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study.
Any signs of active COVID-19 infection on day of visit.
Significantly impaired renal function (eGFR<30 ml/min)
Trial design
Treatments tested in this trial
- Magnetic Resonance Imaging
Treatment groups
750 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov