RADIATE-VT is a pivotal, multicenter, randomized trial comparing safety and efficacy between cardiac radioablation (CRA) using the Varian CRA System and repeat catheter ablation (CA), for patients with high-risk refractory ventricular tachycardia (VT) who have experienced VT recurrence after CA and are candidates for additional CA.
Ischemic and/or nonischemic cardiomyopathy, and
Left ventricular ejection fraction (LVEF) ≤49% and
Previously underwent at least one standard of care CA for VT.
Presence of a clinical indication for a repeat CA procedure for scar-mediated VT in the judgement of the treating investigator.
Contraindication to a CA procedure for VT (e.g., presence of mobile LV thrombus, active systemic infection, active ischemic or other reversible causes of VT).
Patients with expected, right ventricular scar only.
Any prior radiation to the thorax region of the body.
Known medical conditions associated with higher risk of radiotherapy complications in the judgement of the radiation oncologist (i.e., active connective tissue disorders, interstitial lung disease, etc.) that would preclude safe delivery of CRA.