About this trial
Women who experience placental complications (syndromes) during pregnancy, such as pre-eclampsia (high blood pressure and kidney problems), gestational hypertension (high blood pressure during pregnancy) and fetal growth restriction (baby being small) have twice the risk of developing heart disease and diabetes later in life, compared to women who have a healthy pregnancy.
This study aims to assess risk factors for heart disease and diabetes in women who are actively trying to conceive, before and during their pregnancy, and 9-12 months after delivery of their baby, to see whether placental syndromes make a difference to their heart health. This will allow us to understand, if, and how, placental syndromes increase the risk of heart disease and diabetes, and, therefore, how best to reduce this risk and potentially prevent placental syndromes in the future. The investigators will also recruit women who are NOT planning pregnancy, as a control group.
Eligibility criteria
Qualifiers
Nulliparous (no previous pregnancy beyond 20 weeks' gestation)
Actively considering pregnancy within approximately 12 months
Aged between 18 and 45 years
Ability to consent and willing to participate
Disqualifiers
Currently pregnant
Established infertility
Planning or actively using fertility treatments (e.g. IVF, ICSI, FET, IUI)
Assigned male sex at birth
Trial design
Treatments tested in this trial
- Not listed
Trial groups
Sponsors and collaborators
Cambridge University Hospitals NHS Foundation Trust
Lead sponsor
University of Cambridge
Collaborator
University of Bristol
Collaborator
University College, London
Collaborator
King's College London
Collaborator
Imperial College London
Collaborator
St George's, University of London
Collaborator
University of Glasgow
Collaborator
Wellcome Trust
Collaborator