Cardiovascular and Endothelial Markers During OGTT Before and at Six and Twelve Months Post-treatment in Women With PCOS
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18-45
SponsorAttikon Hospital
About this trial
The aim of the present study is to investigate a) the presence of subclinical markers of vascular, myocardial and endothelial function in women with PCOS b) the acute alterations in these markers during the oral glucose tolerance test (OGTT) c) the impact of potential treatment interventions in these markers.
Eligibility criteria
Qualifiers
Age > 16 years old
Clinical or biochemical hyperandrogenism
Anovulation or oligo-ovulation
Polycystic ovarian morphology (PCOM)
Disqualifiers
Disorders with clinical presentation similar to PCOS: thyroid disease, hyperprolactinemia, and non-classic congenital adrenal hyperplasia (primarily 21-hydroxylase deficiency by serum 17-hydroxyprogesterone [17-OHP]), Cushing syndrome, acromegaly
Treatment with contraceptive or metformin
Type 2 diabetes mellitus
Treatment for diabetes
Trial design
Treatments tested in this trial
- GLP-1 receptor agonist
- Oral contraceptive
- Metformin
- Lifestyle modification
Treatment groups
120 Participants
are divided into 4 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov