Short sleep duration confers high cardiovascular and metabolic risk, but lifestyle factors and molecular mechanisms that contribute to increased blood pressure and poor glucose control during short sleep are not completely understood. Habitual short sleepers are constantly eating, the proposed studies will evaluate if this behavior contributes to heightened cardiovascular and metabolic risk. The study will evaluate if restricted eating duration (8 hours/day) could improve cardiovascular and metabolic health in habitual short sleepers.
Age: 18-45 years
BMI: 25-35 kg/m2
Habitual sleep duration: ≤6.5 h/night
Habitual eating period: >14h/day
Irregular sleep habits / night shift / rotating shift work in past 1 month.
Frequent travel related jet lag.
Pregnant/ breast-feeding/ history of irregular menstrual cycles.
Sleep disorders such as insomnia (defined as Insomnia Severity Index score ≥15), and sleep apnea (overnight oximetry defined oxygen desaturation index of >10 events/h of sleep).
Pennington Biomedical Research Center
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator