Causes and Outcomes of Febrile Illness in Health Facilities in Rural South and Southeast Asia
ConditionAcute Febrile Illness
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age29+
SponsorUniversity of Oxford
About this trial
This prospective multi-site observational study aims to describe causes and clinical outcomes of acute febrile illness as well as host biomarkers in patients aged \>28 days residing in rural areas in Laos, Myanmar, Thailand, the Thai-Myanmar border region, and Bangladesh and presenting with acute febrile illnesses (≤ 14 days duration) to participating health facilities.
This study is funded by the UK Wellcome Trust. The grant reference number is 215604/Z/19/Z
Eligibility criteria
Qualifiers
The patient and/or where relevant their parent/guardian/caretaker is willing and able to give informed consent /assent for participation in the study;
Aged > 28 days (day of birth = Day 1);
Axillary temperature at presentation (≥ 37.5°C (99.5°F) OR < 35.5°C (95.9°F)) and no more likely cause than sepsis for hypothermia OR History of fever in the 24 hours prior to presentation;
Onset of illness ≤ 14 days
Disqualifiers
Accident or trauma is the cause for the patient's presentation;
Presentation ≤ 3 days after routine immunisations
Is currently under follow-up or has been afebrile for less than 72 hours after completion of a follow-up period.
The treating healthcare worker's decision is to send the patient home following initial assessment.
Trial design
Treatments tested in this trial
- Not listed
Trial groups
7,200 Participants
are grouped into 1 trial groupSponsors and collaborators
University of Oxford
Lead sponsor
Shoklo Malaria Research Unit (SMRU)
Collaborator
Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit
Collaborator
Building Resources Across Communities (BRAC), Bangladesh
Collaborator
Mahidol Oxford Tropical Medicine Research Unit
Collaborator
Chiang Rai Clinical Research Unit (CCRU), Thailand
Collaborator
Source ClinicalTrials.gov