CAYA Cancer Retrospective Cohort Study

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age0-21
SponsorResonance, Inc.

About this trial

Despite advances in cancer treatment, significant disparities in outcomes persist between high-income countries (HICs) and low-and middle-income countries (LMICs). Around 80% of children with cancer live in LMICs, where they face challenges such as delayed diagnosis, misdiagnosis, comorbidities, distance to treatment, financial barriers, and limited access to risk-adapted therapies.

Acute lymphoblastic leukemia(ALL)/lymphoblastic lymphoma(LBL), for example, is one of the greatest success stories in pediatric oncology, however, such improvements are not evenly distributed worldwide, and the outcomes for leukemia patients are poorer in LMICs compared to HICs, primarily due to reduced access to quality healthcare.

This study aims to assess cancer treatment outcomes in LMICs, focusing on acute lymphoblastic leukemia/lymphoblastic lymphoma. The findings will inform future studies to implement evidence-based interventions that improve care quality and reduce treatment failures through targeted strategies.

Eligibility criteria

Qualifiers

Participants must be willing and able to provide informed consent prior to enrollment in the registry.

For minors or individuals unable to provide informed consent, assent must be obtained along with consent from a legal guardian.

Note: Exemption applies to this criterion when waiver of informed consent/assent is granted by Institutional Review Board(IRB)/Independent Ethics Committee(IEC)/Competent Authorities(CAs).

A confirmed diagnosis of any type of cancer within the 15 years prior to the site's activation date.

Disqualifiers

Consultation without subsequent primary anti-cancer treatment at the participating center

Pathology, radiology, or other diagnostic evaluations without treatment

Trial design

Treatments tested in this trial

  • Retrospective Medical Record Review

Treatment groups

18,000 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Resonance, Inc.

Lead sponsor

Servier Affaires Médicales

Collaborator