About this trial
Depression in youth is a serious public health concern for which more personalized treatments are needed. This randomized controlled trial will test the effect of an intervention aimed at enhancing social cognitive capacities (e.g., ability to take another's perspective), thereby making treatment of depression in youth more efficient and effective. Participants in the R33 (N=82) will be youth between ages 13- through 17-years-old currently experiencing depression. Youth will be randomized to either an enhanced CBT intervention that teaches social cognitive skills, particularly social perspective taking and theory of mind (CBTSCT) as compared to CBT only. The primary target is improvement in both social cognitive skills and depressive symptoms at post-treatment and at a 6-month follow-up.
Eligibility criteria
Qualifiers
Participants ages 13- through 17-years-old
Youth must have a diagnosis of a current depressive disorder (e.g., major depressive episode; persistent depressive disorder) or a score on the Patient Health Questionnaire (PHQ9) > 15
Disqualifiers
ever met criteria for a diagnosis of bipolar disorder, schizophrenia, autism, or conduct disorder
current alcohol or substance use disorder with significant impairment
imminent risk of suicide
reading level < 4th grade
Trial design
Treatments tested in this trial
- Cognitive behavioral therapy plus social cognitive training (CBTSCT)
Treatment groups
Sponsors and collaborators
Vanderbilt University
Lead sponsor
National Institute of Mental Health (NIMH)
Collaborator