About this trial
A randomized, single-blind study comparing two pacing strategies in patients with atrioventricular block requiring permanent pacemaker implantation. This trial evaluates the impact of conduction system pacing (left bundle branch area pacing) versus standard right ventricular pacing on central hemodynamics, cardiac function, and patient quality of life over 12 months. The study will enroll 124 patients from two Estonian tertiary hospitals and measure central systolic arterial pressure as the primary outcome, with secondary assessments of arterial stiffness, echocardiographic parameters, electrical activation patterns, and quality of life scores.
Eligibility criteria
Qualifiers
Age 18-80 years
Diagnosis of atrioventricular block
Expected survival >1 year
Disqualifiers
Reduced left ventricular ejection fraction (EF <45%)
Expected ventricular pacing burden <20%
Inter-arm systolic blood pressure difference >15 mmHg
Percutaneous coronary intervention or coronary artery bypass surgery within the last 30 days
Trial design
Treatments tested in this trial
- Right ventricular pacing
- Conduction system pacing
Treatment groups
Sponsors and collaborators
University of Tartu
Lead sponsor
North Estonia Medical Centre
Collaborator
Tartu University Hospital
Collaborator