Central Haemodynamics and Pacing for AV Block

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorUniversity of Tartu

About this trial

A randomized, single-blind study comparing two pacing strategies in patients with atrioventricular block requiring permanent pacemaker implantation. This trial evaluates the impact of conduction system pacing (left bundle branch area pacing) versus standard right ventricular pacing on central hemodynamics, cardiac function, and patient quality of life over 12 months. The study will enroll 124 patients from two Estonian tertiary hospitals and measure central systolic arterial pressure as the primary outcome, with secondary assessments of arterial stiffness, echocardiographic parameters, electrical activation patterns, and quality of life scores.

Eligibility criteria

Qualifiers

Age 18-80 years

Diagnosis of atrioventricular block

Expected survival >1 year

Disqualifiers

Reduced left ventricular ejection fraction (EF <45%)

Expected ventricular pacing burden <20%

Inter-arm systolic blood pressure difference >15 mmHg

Percutaneous coronary intervention or coronary artery bypass surgery within the last 30 days

Trial design

Treatments tested in this trial

  • Right ventricular pacing
  • Conduction system pacing

Treatment groups

124 Participants
are divided into 2 treatment groups

Sponsors and collaborators

University of Tartu

Lead sponsor

North Estonia Medical Centre

Collaborator

Tartu University Hospital

Collaborator