About this trial
This study aims to compare the effectiveness of cervical cerclage combined with progesterone versus progesterone alone in preventing preterm birth among women with twin pregnancies and a short cervix (cervical length ≤ 30 mm). Participants will be randomly allocated to either the intervention group (cerclage plus progesterone) or the control group (progesterone alone).
Eligibility criteria
Qualifiers
Maternal age ≥ 18
Twin pregnancy
Asymptomatic short cervix (CL≤30mm) at routine ultrasound investigation
Gestational age at 16+0- 24+0 weeks
Disqualifiers
Women with twin pregnancy in which one or both fetuses are diagnosed with a major structural or congenital abnormality that is likely to influence the composite adverse neonatal outcome.
Women with a monochorionic monoamniotic twin pregnancy
A monochorionic twin pregnancy with twin-to-twin transfusion syndrome before or at the time of inclusion.
Patients have indications for vaginal cerclage: Recurrent late miscarriage (from 14 weeks) or preterm birth occurring two or more times.
Trial design
Treatments tested in this trial
- Cervical cerclage
- Progesterone
Treatment groups
Sponsors and collaborators
National Hospital of Obstetrics and Gynecology
Lead sponsor
Quang Ninh Obstetrics and Pediatrics Hospital, Quang Ninh, Vietnam
Collaborator
Ninh Binh Obstetrics and Pediatrics Hospital, Ninh Binh, Vietnam
Collaborator
Bac Ninh 1 Obstetrics and Pediatrics Hospital, Bac Ninh, Vietnam
Collaborator
Bac Ninh 2 Obstetrics and Pediatrics Hospital, Bac Ninh, Vietnam
Collaborator
Hung Yen Obstetrics and Pediatrics Hospital, Hung Yen, Vietnam
Collaborator