To investigate the mechanism and efficacy of a novel repetitive transcranial magnetic stimulation (rTMS) intervention model with paired cerebellar-medial prefrontal cortex (mPFC) pulses on methamphetamine use disorder patients and to develop a novel physiotherapeutic intervention to optimise the treatment and management.
Methamphetamine is the primary substance of use, and the participant meets the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria for moderate or severe methamphetamine use disorder;
aged 18 to 60 years;
normal or corrected-to-normal vision and hearing, and right-handedness;
primary school education or above, with the ability to understand the questionnaires and behavioral task instructions.
presence of metal objects in the body, such as metal dentures, orthodontic braces, bone fixation plates, aneurysm clips, or other metallic implants;
severe physical illness or chronic disease, including heart disease, severe hypertension, stroke, epilepsy, or history of head trauma;
comorbid psychiatric disorders, such as bipolar disorder, schizophrenia, or severe depression;
previous participation in transcranial magnetic stimulation- or electroencephalography-related studies;
Shanghai Mental Health Center
Lead sponsor
Chengdu Drug Rehabilitation Center
Collaborator
Sichuan Ziyang Compulsory Isolation Drug Rehabilitation Center
Collaborator
Mental Health Center, West China Hospital of Sichuan University, Chengdu
Collaborator
Wuhan Mental Health Center, The Ninth Clinical School, Tongji Medical College, Huazhong University of Science and Technology, Wuhan
Collaborator
HanYang Comoulsory Isolation Drug Rehabilitation Center, Wuhan
Collaborator