This is an observational study to better understand the risk factors and progression of CADASIL, a leading cause of vascular cognitive impairment and dementia (VCID). 575 participants will be enrolled and can expect to be on study for up to 5 years.
Must be at least 18 years old
Positive NOTCH3 genetic testing; OR a positive skin biopsy; OR a willingness to have a NOTCH3 genetic test completed prior to enrolling AND are at-risk for, or diagnosed clinically with, CADASIL
Willing to commit to three in-person visits (a baseline visit, an 18-month follow-up, and a 36-month follow-up) and to remote visits as needed by phone, email, mail or internet
Willing to provide documentation of all current medications to study team
History of severe learning disability, intellectual disability, or other neurological disease or event not attributable to CADASIL
History of serious alcohol or drug abuse within the past year
Unwilling to undergo NOTCH3 genetic testing if there is no test on file
University of Wisconsin, Madison
Lead sponsor
National Institute on Aging (NIA)
Collaborator