Cerebral Small Vessel Disease Progression Dependent on Stroke Type
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorJohannes Dorst
About this trial
The goal of this prospective, observational study is to understand if cerebral small vessel disease (CSVD) has different velocities and patterns of temporal development, dependent on a concurrent ischemic stroke. It focusses on adult patients with known or newly diagnosed CSVD on magnetic resonance imaging. The study will evaluate if blood based, in parts central nervous system specific protein markers, so called biomarkers, have an additional value reflecting the course of CSVD as defined per MRI assessments. Further patient-relevant endpoints include neuropsychological abilities, neurological functional outcomes, quality of life assessments, stroke recurrence risk.
Eligibility criteria
Qualifiers
Age ≥ 18 years
Evidence of cerebral small vessel disease on brain MRI, defined as white matter hyperintensities (Fazekas grade 1-3)
cerebral small vessel disease without evidence of an acute ischemic stroke
cerebral small vessel disease with acute lacunar ischemic stroke
Disqualifiers
Alternative plausible causes of white matter hyperintensities other than cerebral small vessel disease (e.g. inflammatory central nervous system disorders, leukodystrophies, brain tumors)
Known neurodegenerative diseases (e.g. Parkinson's disease, Alzheimer's disease, other dementias)
Acute or recent traumatic brain injury
Contraindications to magnetic resonance imaging
Trial design
Treatments tested in this trial
- Not listed
Trial groups
180 Participants
are grouped into 3 trial groupsSponsors and collaborators
Johannes Dorst
Lead sponsor
University Hospital Ulm
Sponsor institution
Source ClinicalTrials.gov