About this trial
The goal of this study is to learn about the body's response to cannabis based products in sleep deprived people who are currently experiencing anxiety but are otherwise healthy.
Eligibility criteria
Qualifiers
Aged 18-60
Currently experiencing higher than average anxiety (measured by a score of ≥10 on the GAD-7)
Able and willing to restrict their sleep to 4 hours on one occasion
Willing to restrict alcohol and recreational drug intake during time on the study, confirmed by negative urine drug screen on the day of the experimental session
Disqualifiers
Currently receiving any treatment for any psychiatric disorder (medication and/or professional psychotherapy for a mental disorder)
Any cannabinoid use in the past 3 months, including CBD oil, medical cannabinoids or recreational cannabis/THC use
Cannabinoid contraindications: lifetime history of psychosis, 1st degree relative with psychosis, lifetime substance use disorder (that was professionally treated)
History of consistent (>12 months) monthly cannabis use
Trial design
Treatments tested in this trial
- THC
- CBD
- THC + CBD
- Placebo
Treatment groups
Sponsors and collaborators
King's College London
Lead sponsor
South London and Maudsley NHS Foundation Trust
Collaborator