CHAMP Lung Cancer Screening Program

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age50-77
SponsorJill Kolesar

About this trial

The U.S. Preventive Services Task Force recommends annual lung cancer screening (LCS) with low-dose CT for adults aged 50-80 with a ≥20 pack-year smoking history who currently smoke or quit within the past 15 years. Despite insurance coverage, only 17% of eligible Iowans were screened in 2024. Barriers include the complexity of screening and competing demands in primary care. To address these challenges, investigators propose a two-part intervention: a blood-based screening test to simplify LCS and a community pharmacist-led referral program integrated into routine pharmacy care.

Eligible patients will be identified at Greenwood Pharmacy in Waterloo, Iowa. Interested individuals will be consented by a pharmacist and engaged in shared decision-making about LCS. Participants may decline screening, complete the DELFI Diagnostics FirstLook lung cancer screening blood test, or pursue CT screening through their primary care physician. Those choosing the blood test will be referred to Cedar Valley Family Medicine. Patients with a positive result will complete a standard shared decision-making visit with their PCP and, if appropriate, undergo confirmatory CT imaging. Patients with a negative result will enter a screening cohort and be re-screened annually for an additional year.

Eligibility criteria

Qualifiers

aged 50-77

smoking pack-year history of ≥ 20 years

current smoker or quit smoking 15 or less years ago

ability to understand and willingness to sign a written informed consent document

Disqualifiers

self-report of lung cancer screening in the last 12 months

psychiatric illness/social situations that would limit compliance with study requirements

Trial design

Treatments tested in this trial

  • DELFI Diagnostics FirstLook Lung Cancer Screening Blood Test
  • Low-Does CT Scan

Treatment groups

300 Participants
are divided into 3 treatment groups

Sponsors and collaborators

Jill Kolesar

Lead sponsor

University of Iowa

Sponsor institution

Eli Lilly and Company

Collaborator