The PLACARD research project aims to investigate the impact of CPB-induced platelet modifications during cardiac surgery on the post-operative inflammatory response and bleeding complications. Our objectives are to study the impact of CPB on the formation of procoagulant platelets, to assess changes in platelet lipid profile and bioenergetics before, during and after cardiac surgery, and to connect the ex-vivo observations to post-operative clinical and biological parameters of these patients during their stay in cardiovascular intensive care unit.
Adult patients (≥ 18 years old) suffering from coronary disease and/or severe valvular dysfunction (mitral or aortic) undergoing elective coronary angiography or cardiac surgery with cardiopulmonary bypass.
Uninterrupted preoperative dual antiplatelet therapy
Active chronic inflammatory disease
Recent chemotherapy or immunotherapy (< 3 months)
Active solid malignancy
Université Catholique de Louvain
Lead sponsor
Fonds National de la Recherche Scientifique
Collaborator
Fondation Mont-Godinne
Collaborator