The PLACARD research project aims to investigate the impact of CPB-induced platelet modifications during cardiac surgery on the post-operative inflammatory response and bleeding complications. Our objectives are to study the impact of CPB on the formation of procoagulant platelets, to assess changes in platelet lipid profile and bioenergetics before, during and after cardiac surgery, and to connect the ex-vivo observations to post-operative clinical and biological parameters of these patients during their stay in cardiovascular intensive care unit.
Adult patients (≥ 18 years old) suffering from coronary disease and/or severe valvular dysfunction (mitral or aortic) undergoing elective coronary angiography or cardiac surgery with cardiopulmonary bypass.
Uninterrupted preoperative dual antiplatelet therapy
Active chronic inflammatory disease
Recent chemotherapy or immunotherapy (< 3 months)
Active solid malignancy
Parallel
Arterial blood sample
Biological/VaccineAn arterial blood sample will be obtained at the beginning of the coronary angiography by using the arterial sheat in place, before administration of Heparin.
Arterial blood sample
Biological/VaccineAn arterial blood sample will be obtained via the arterial line before anesthetic induction, 60 minutes after the beginning of cardiopulmonary bypass and 4 hours after the arrival in the intensive care unit
Procoagulant platelet formation
Ex-vivo flow cytometric assessment of the pourcentage of procoagulant platelet population under basal and stimulated conditions.
Platelet lipidomics
Assessment of the impact of cardiac surgery and cardiopulmonary bypass on platelet lipid metabolism. Pourcentage of patients with platelet Acety-CoA Carboxylase phosphorylation.
Postoperative bleeding
Correlation between the ex-vivo primary outcomes and clinical postoperative parameters (chest drain output (mL) and need for blood transfusion (units of packed red cells, fresh frozen plasma, platelets and fibrinogen)).
Postoperative inflammation
Correlation between the ex-vivo primary outcomes and biological postoperative parameters (C-reactive protein).
Postoperative platelet function
Correlation between the ex-vivo primary outcomes and biological postoperative parameters (platelet aggregometry results).
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Université Catholique de Louvain
Lead sponsor
Fonds National de la Recherche Scientifique
Collaborator
Fondation Mont-Godinne
Collaborator
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