Acute ischaemic stroke (AIS) results in high rates of neurological morbidity and mortality, especially in patients with large vessel occlusion (LVO). Endovascular therapy (EVT) has been approved as the most effective treatment for patients with LVO , but about half patients undergoing EVT did not achieve good outcome. The mechanisms of poor prognosis are complex. How to accurately identify serological biomarkers related to patients' clinical prognosis is an important research topic nowadays.
Age: 18-80 years;
Patients with acute anterior circulation large vessel occlusion within 24 hours of onset who will receive endovascular treatment;
Pre-stroke mRS: 0-1;
Baseline NIHSS: ≥6;
The presence of contraindications to internal jugular vein cannulation;
Receiving intravenous thrombolysis;
Haemorrhagic stroke (cerebral haemorrhage or subarachnoid haemorrhage);
Coagulation disorders, systemic bleeding tendency, thrombocytopenia (<100×109/L);