Characterisation of Endothelial Cells in Different Inflammatory Pathologies
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorRoyal Surrey County Hospital NHS Foundation Trust
About this trial
The goal of this observational study is to characterise changes in gene expression in endothelial cells in patients with either sepsis or post major abdominal surgery.
The main question we plan to answer is: 'What molecular pathways are differentially expressed during inflammatory pathologies?'
Eligibility criteria
Qualifiers
Adult ≥ 18 years
Able and willing to give consent
Adult ≥ 18 years
Patients admitted to RSFT for planned major surgery
Disqualifiers
Not currently a patient within the hospital
Absence of inflammatory diseases and disorders including but not limited to arthritis, peripheral artery disease, vasculitis, diabetes, cardiovascular disease and CKD.
Not on immunomodulatory medications, such as corticosteroids
History of recent major trauma within the last 2 months (e.g., surgery or injury requiring hospitalisation)
Trial design
Treatments tested in this trial
- Endothelial cell biopsy
Treatment groups
105 Participants
are divided into 5 treatment groupsSponsors and collaborators
Royal Surrey County Hospital NHS Foundation Trust
Lead sponsor
University of Surrey
Collaborator
Source ClinicalTrials.gov