About this trial
The goal of this clinical trial is to improve the treatment of hepatic steatosis associated with obesity with pharmacological and nutritionnal approaches. The main question it aims to answer is:
Does an individualized nutritionnal approach with a dietician combined with medication targeting obesity is the most efficient way to treat hepatic steatosis associated with obesity?
Participants will either participate in one of three groups:
* Nutrition: Participant will only have a regular follow-up with a registered dietician; * Nutrition + Semaglutide: Participants will start a new medication targeting obesity and will have a regular follow-up with a registered dietician; * Semaglutide: Participants will start a new medication targeting obesity.
Eligibility criteria
Qualifiers
Body mass index between 30 and 50 kg/m2;
Stade 2 or 3 (S2 or S3) hepatic steatosis with or without liver fibrosis.
Disqualifiers
Type 1 diabetes diagnosis;
Alcohol consumption exceeding recommendations [>140 g/week (women) and >210 g/week (men)];
Known chronic hepatic disease non-steatotic at the entry of the study (Wilson's disease, hemochromatosis, alpha-1-antitrypsin deficiency, viral hepatitis, auto-immune hepatitis, etc.);
Pharmacological treatment targeting obesity active or ended in the last 3 months;
Trial design
Treatments tested in this trial
- semaglutide
- Diet