Characterization and Management of Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorInstitut universitaire de cardiologie et de pneumologie de Québec, University Laval

About this trial

The goal of this clinical trial is to improve the treatment of hepatic steatosis associated with obesity with pharmacological and nutritionnal approaches. The main question it aims to answer is:

Does an individualized nutritionnal approach with a dietician combined with medication targeting obesity is the most efficient way to treat hepatic steatosis associated with obesity?

Participants will either participate in one of three groups:

* Nutrition: Participant will only have a regular follow-up with a registered dietician; * Nutrition + Semaglutide: Participants will start a new medication targeting obesity and will have a regular follow-up with a registered dietician; * Semaglutide: Participants will start a new medication targeting obesity.

Eligibility criteria

Qualifiers

Body mass index between 30 and 50 kg/m2;

Stade 2 or 3 (S2 or S3) hepatic steatosis with or without liver fibrosis.

Disqualifiers

Type 1 diabetes diagnosis;

Alcohol consumption exceeding recommendations [>140 g/week (women) and >210 g/week (men)];

Known chronic hepatic disease non-steatotic at the entry of the study (Wilson's disease, hemochromatosis, alpha-1-antitrypsin deficiency, viral hepatitis, auto-immune hepatitis, etc.);

Pharmacological treatment targeting obesity active or ended in the last 3 months;

Trial design

Treatments tested in this trial

  • semaglutide
  • Diet

Treatment groups

120 Participants
are divided into 3 treatment groups