Characterization Imaging Instruments in Alcoholics and Non-Alcoholics
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorNational Institute on Alcohol Abuse and Alcoholism (NIAAA)
About this trial
Background:
\- People with alcoholism have differences in their brains compared with healthy people. People who are dependent on alcohol also perform differently on behavioral tasks. Researchers want to find out more about these differences. They also want to see if these differences are related to DNA.
Objective:
\- To see if differences in brain structure relate to personality and behavior differences in people with and without alcohol dependence.
Eligibility:
\- Adults age 18 and older.
Design:
* Participants will visit the NIH Clinical Center once during the study. * Participants will be screened with a medical history, EKG, and physical exam. They will give blood and urine samples and undergo a psychiatric interview. * Participants will be asked about their alcohol drinking, to see if they have an alcohol use disorder. * Participants will play three computerized games. Some will play these games inside a magnetic resonance imaging (MRI) scanner. * MRI: strong magnetic field and radio waves take pictures of the brain. Participants lie on a table that slides in and out of a cylinder. They will be in the scanner for about 90 minutes. They may lie still for up to 20 minutes at a time. The scanner makes loud knocking noises. They will get earplugs.
Eligibility criteria
Qualifiers
Age 18 years or older,
Have been pre-screened, determined eligible for any NIAAA study, or enrolled in any
Disqualifiers
Positive BrAC#,
Positive urine drug test (UDT) # for benzodiazepines, cocaine, methamphetamines, and opiates for outpatients. Positive UDT for benzodiazepines is not exclusionary for the inpatients. It is common that the inpatients who are treated for AUD withdrawal are treated with benzodiazepines. Positive THC would also not be exclusionary for this study since it tends to be detected over the long period of time after use. However, we will make note of these for the data analysis purposes.
Task performance (behavioral, fMRI) only: cleared based on neuromotor examination,
Presence of ferromagnetic objects in the body that are contraindicated for MRI of the head (pacemakers or other implanted electrical devices, brain stimulators, some types of dental implants, aneurysm clips, metallic prostheses, permanent eyeliner, implanted delivery pump, or shrapnel fragments),
Trial design
Treatments tested in this trial
- Not listed
Trial groups
1,000 Participants
are grouped into 2 trial groupsSponsors and collaborators
Source ClinicalTrials.gov