Characterization of Clinical Phenotypes of Laryngeal Dystonia and Voice Tremor

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorMassachusetts Eye and Ear Infirmary

About this trial

The researchers will systematically evaluate current and novel clinical voice assessment tools and measures to elucidate distinct clinical phenotypes of those with laryngeal dystonia and voice tremor.

Eligibility criteria

Qualifiers

Males and females of diverse racial and ethnic backgrounds;

Age 18-80 years;

Native English speakers;

Right-handed;

Disqualifiers

Subjects who are incapable of giving informed consent;

Pregnant or breastfeeding women until a time when they are no longer pregnant or breastfeeding. All women of childbearing potential will have a urine pregnancy test performed before MRI, which must be negative for participation in the imaging studies;

Subjects with a past or present medical history of (a) neurological problems, such as stroke, movement disorders (other than specified LD and VT in the patient groups), brain tumors, traumatic brain injury with loss of consciousness, ataxias, myopathies, myasthenia gravis, demyelinating diseases; (b) psychiatric problems, such as schizophrenia, bipolar depression, obsessive-compulsive disorder, alcoholism, drug dependence; (c) laryngeal problems, such as vocal fold paralysis, paresis, vocal fold nodules and polyps, carcinoma, chronic laryngitis;

Patients with any other form of dystonia;

Trial design

Treatments tested in this trial

  • Clinical assessments of laryngeal function

Treatment groups

165 Participants
are divided into 3 treatment groups

Sponsors and collaborators