Characterization of Left Atrial Substrate in Patients With Ventricular Arrhythmias
ConditionAtrial Remodeling
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversitair Ziekenhuis Brussel
About this trial
The goal of this observational study is to analyze the characteristics of left atrial electroanatomical maps in patients without a history of atrial fibrillation but with a high clinical risk of developing it, as indicated by the presence of structural heart disease or a CHA2DS2-VASc score ≥ 2 points. The study cohort will be compared to a historical cohort of patients with diagnosed atrial fibrillation in a propensity-matched fashion.
The main questions it aims to answer are:
* Are the left atrial electroanatomical changes a consequence or a precursor to the development of atrial fibrillation? * Are the left atrial electroanatomical findings different between patients with atrial fibrillation and those at high risk of developing it? * What is the prognostic impact of left atrial pathologic changes in patients without diagnosed atrial fibrillation in terms of cardiovascular outcomes?
Eligibility criteria
Qualifiers
Absence of a prior history of atrial fibrillation or flutter.
Patients presenting for ablation of any ventricular tachycardia related to structural heart disease or any ventricular arrhythmia with a CHA2DS2-VASc score ≥ 2.
Disqualifiers
Presence of thrombus in the left atrial appendage.
Complications related to the index procedure.
Insufficient quality of the left atrial electroanatomical map.
Trial design
Treatments tested in this trial
- Left atrial electroanatomical mapping
Treatment groups
50 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov