Chemotherapy-induced Cognitive and Brain Changes in Older Adults With Breast Cancer
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age60+
SponsorMassachusetts General Hospital
About this trial
This research study evaluates the effect of chemotherapy on cognition (thinking) and the brain in people with breast cancer.
Eligibility criteria
Qualifiers
Breast cancer patients treated with chemotherapy- Group 1 (experimental group)
Participants must meet the following criteria on screening examination to be eligible to participate in the behavioral +/- imaging components of study
New diagnosis histologically confirmed invasive breast cancer
Treatment plan to include chemotherapy
Disqualifiers
Participants with clinical or radiographic evidence of metastatic CNS disease
Subjects with MMSE scores below 24
Active or history of major psychiatric disorders such as schizophrenia, schizoaffective disorder, major affective disorder in mid-life, or treatment with ECT (Mild depression that is well treated with stable dose of SSRI antidepressants may be allowed).
Substance abuse within the past 2 years
Trial design
Treatments tested in this trial
- Cognitive, functional and subjective assessments
- MRI
- PET Scan
Treatment groups
200 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov