About this trial
Heart failure (HF) is a significant cause of death and the leading cause of hospitalization in patients over 65 years of age. Congestion is the main source of symptoms and the leading cause of hospitalization for HF. Furthermore, congestive signs identified in asymptomatic patients are associated with the risk of developing symptomatic HF. The literature supports a multi-modality / integrative evaluation of congestion, combining clinical examination, laboratory results and ultrasound evaluation.
The main objective of the CHF-COVReduced study is to identify congestion markers (clinical, biological and ultrasound) quantified during a consultation or day hospitalization for the monitoring of chronic HF with reduced left ventricular ejection fraction that are associated with the risk of all-cause death, hospitalization for acute HF or IV diuretics injection in a day hospital.
Eligibility criteria
Qualifiers
Patients with chronic acute heart failure with reduced ventricular ejection fraction admitted in hospital for scheduled day hospitalization or in consultation
Patient with altered (left ventricular ejection fraction <40%) and moderately altered (left ventricular ejection fraction between 40 and 50%) left ventricular ejection fraction
Age ≥18 years
Patients having received complete information regarding the study design and having signed their informed consent form.
Disqualifiers
Comorbidity for which the life expectancy is ≤ 3 months
Dialysis patient (peritoneal dialysis or hemodialysis) or patients with glomerular filtration rate <15 ml/min/m2 at inclusion.
History of lobectomy or pneumonectomy lung surgery
Severe pulmonary or pleural pathology preventing reliable acquisition of lung ultrasound images: severe emphysema, chronic pleurisy, pulmonary fibrosis, etc.
Trial design
Treatments tested in this trial
- Clinical examination centered on congestion
- Cardiac, pulmonary, peritoneal, jugular and renal Doppler ultrasounds
- Blood sample retrieved for biological assessment and biobanking
- Telephone follow-up
- Kansas City Cardiomyopathy Questionnaire (KCCQ)
Treatment groups
Sponsors and collaborators
Pr. Nicolas GIRERD
Lead sponsor
Central Hospital, Nancy, France
Sponsor institution