Childhood Cancer Survivor Study
ConditionCancer
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorSt. Jude Children's Research Hospital
About this trial
The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer and its associated therapies. A retrospective cohort study will be conducted through a multi-institutional collaboration, which will involve the identification and active follow-up of a cohort of approximately 50,000 survivors of cancer, diagnosed before 21 years of age, between 1970 and 1999 and 10,000 sibling controls. This project will study children and young adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, who are at increased risk of late-occurring adverse health outcomes. A group of sibling controls will be identified and data collected for comparison purposes.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, Wilms tumor, neuroblastoma, or soft tissue sarcoma before age 21 years between January 1, 1970 and December 31, 1986 at one of participating centers.
Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor, kidney tumor, neuroblastoma, or rhabdomyosarcoma before age 21 years between January 1, 1987 and December 31, 1999 at one of participating centers.
English- or Spanish-speaking and living in the U.S. or Canada at the time of diagnosis.
Disqualifiers
Diagnosis of non-malignant tumors (i.e., Langerhans cell histiocytosis, meningioma, craniopharyngioma, etc.) treated with radiation and/or chemotherapy.
Non-English speaking or residence outside the US or Canada.
For comparison purposes, a group of sibling controls will be identified to represent a stratified random sample based on the distribution of survivors with regard to cancer diagnosis, age, sex, race, and geographic location.
Trial population
Newly diagnosed with cancer between January 1, 1970 and December 31, 1999 at one of the participating centers noted below or identified as sibling control.
Trial design
Design model
Cohort
Time perspective
Retrospective
Treatments tested in this trial
Not listed
Trial groups
50,000 Participants
are grouped into 2 trial groupsGroup A: Cancer survivors
Group B: Sibling Controls
Trial outcomes
Primary outcomes
1
To characterize survivors' health outcomes with respect to disease-, treatment, and genetic-related factors.
Time frame
25 yearsSponsors and contacts
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St. Jude Children's Research Hospital
Lead sponsor
National Cancer Institute (NCI)
Collaborator
Fred Hutchinson Cancer Center
Collaborator
Nationwide Children's Hospital
Collaborator
M.D. Anderson Cancer Center
Collaborator
University of Southern California
Collaborator
Children's Hospital Medical Center, Cincinnati
Collaborator
University of California, San Francisco
Collaborator
Source ClinicalTrials.gov