The aim of this study is to establish and perfect the China Cognition and Aging Study (China COAST) cohort, to clarify the epidemiology, influencing factors, genetic characteristics, pathogenesis, disease characteristics and diagnosis and treatment status of dementia and its subtypes in China. It is of great significance to establish a relatively comprehensive national database of cognitive disorders, improve the clinical diagnosis and treatment level of cognitive disorders, and formulate prevention and treatment strategies for dementia. The primary aims of China COAST are as follows:
1. To use the prospective cohort to establish a large database research platform, so as to provide comprehensive epidemiological data, clinical and neuropsychological evaluation data, biological samples, and laboratory tests and imaging data. 2. To update the prevalence and incidence rate of dementia and its subtypes every 2-3 years, and clarify the conversion pattern from normal elderly to MCI and from MCI to dementia. 3. To explore the known or unknown protective and risk factors of dementia and its major subtypes (AD, VaD, other dementia). 4. To discover new pathogenic genes and susceptible genes of dementia and its major subtypes (AD and VaD), as well as new mutation sites of known pathogenic genes. To study the genetic variation, mutation and polymorphism of PSEN1, PSEN2, APP and APOE genes in dementia patients, and to understand their distribution and roles in the pathogenesis. 5. To study the biomarkers (body fluid, genetics, imaging) with diagnostic value of MCI, AD (sporadic and familial) and VaD, to define their cut-off values, and to establish prediction models. 6. To study the diagnostic criteria of cognitive normal, MCI, dementia and their subtypes (clinical and molecular subtypes) in the cohort, and to make psychological assessment scales with high sensitivity and specificity, and in line with the characteristics of Chinese people. 7. To find potentially modifiable risk factors for dementia and to study the prevention and intervention effect of non-pharmacological treatment on APOE ε4 carriers, MCI and AD or other dementia patients，which included improvements in education, nutrition, health care, and lifestyle changes. This needs a long time follow-up. 8. To explore the relationship between dementia as well as its major subtype AD and cerebral and systemetic circulatory disorders (for example, mixed dmentia), as well as potential therapeutic strategies. 9. To carry out investigation and researches about dementia related education, improve the awareness of dementia, and strengthen the management of dementia. 10. To investigate the level of stigma and discrimination and its influencing factors in patients with Alzheimer's disease and their caregivers.
Diagnosis according to 2004 Peterson's MCI criteria.
CDR = 0.5.
Memory loss is prominent, and may also be with other cognitive domain dysfunction.
Insidious onset, slow progress.
With history of stroke and a neurological focal sign, the imaging findings are consistent with cerebral small vessal disease (Fazekas score ≥ 2 points).
Other neurological diseases that can cause brain dysfunction (such as depression, brain tumor, Parkinson's disease, metabolic encephalopathy, encephalitis, multiple sclerosis, epilepsy, brain trauma, normal intracranial pressure hydrocephalus, etc.).
Other systemic diseases that can cause cognitive impairment (such as liver, renal and thyroid insufficiency, severe anemia, folic acid or vitamin B12 deficiency, syphilis, HIV infection, alcohol and drug abuse, etc.).
Mental and neurodevelopmental retardation.
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Trial groupsSee each trial group below.
Capital Medical University
Lead sponsor
Beijing Tiantan Hospital
Collaborator
Beijing Chao Yang Hospital
Collaborator
Fu Xing Hospital, Capital Medical University
Collaborator
Peking Union Medical College Hospital
Collaborator
Peking University First Hospital
Collaborator
Peking University Third Hospital
Collaborator
Chinese PLA General Hospital
Collaborator
China-Japan Friendship Hospital
Collaborator
Beijing Geriatric Hospital
Collaborator
The First Affiliated Hospital of Dalian Medical University
Collaborator
Fujian Medical University Union Hospital
Collaborator
Guangzhou Psychiatric Hospital
Collaborator
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Collaborator
First Affiliated Hospital of Guangxi Medical University
Collaborator
The Affiliated Hospital Of Guizhou Medical University
Collaborator
Handan Central Hospital
Collaborator
Hebei General Hospital
Collaborator
First Hospital of Shijiazhuang City
Collaborator
Tangshan Worker's Hospital
Collaborator
Hunan Provincial People's Hospital
Collaborator
Kaifeng Central Hospital
Collaborator
People's Hospital of Zhengzhou University
Collaborator
Zhongnan Hospital
Collaborator
First Affiliated Hospital of Harbin Medical University
Collaborator
Tongji Hospital
Collaborator
People's Hospital Affiliated Hubei Medical University
Collaborator
The Third Xiangya Hospital of Central South University
Collaborator
Xiangya Hospital of Central South University
Collaborator
The First Hospital of Jilin University
Collaborator
China-Japan Union Hospital, Jilin University
Collaborator
Subei People's Hospital of Jiangsu
Collaborator
Nantong University Affiliated Hospital
Collaborator
Mineral General Hospital, Xuzhou
Collaborator
Jiangxi Provincial People's Hopital
Collaborator
Anshan Central Hospital
Collaborator
Affiliated Zhongshan Hospital of Dalian University
Collaborator
First Hospital of China Medical University
Collaborator
Baotou Central Hospital
Collaborator
General Hospital of Ningxia Medical University
Collaborator
The People's Hospital of Ningxia
Collaborator
The Affiliated Hospital of Qingdao University
Collaborator
The 960th Hospital of PLA
Collaborator
Qilu Hospital of Shandong University
Collaborator
Qilu Hospital of Shandong University (Qingdao)
Collaborator
Shandong Provincial Hospital
Collaborator
Qingdao Municipal Hospital
Collaborator
The First Affiliated Hospital of Shanxi Medical University
Collaborator
Tang-Du Hospital
Collaborator
First Affiliated Hospital Xi'an Jiaotong University
Collaborator
Ruijin Hospital
Collaborator
RenJi Hospital
Collaborator
Shanghai Changzheng Hospital
Collaborator
Affiliated Hospital of North Sichuan Medical College
Collaborator
Tianjin Huanhu Hospital
Collaborator
Tianjin Medical University General Hospital
Collaborator
Traditional Chinese Medicine Hospital of Xinjiang Autonomous Region
Collaborator
Ningbo Medical Center Lihuili Hospital
Collaborator
First Affiliated Hospital of Wenzhou Medical University
Collaborator
First Affiliated Hospital of Zhejiang University
Collaborator
Shao Yifu Hospital of Zhejiang Medical University
Collaborator
Zhejiang Provincial People's Hospital
Collaborator
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Collaborator
The Second Affiliated Hospital of Chongqing Medical University
Collaborator
The First Affiliated Hospital of Anhui Medical University
Collaborator
People's Hospital of Chongqing
Collaborator
Dongfang Hospital Beijing University of Chinese Medicine
Collaborator
Zigong No.1 Peoples Hospital
Collaborator