China Early Esophageal Cancer Cohort
ConditionEarly Esophageal Cancer
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age15-85
SponsorChanghai Hospital
About this trial
With the development of endoscopy, more and more patients with superficial esophageal squamous cell carcinoma (ESCC) receive endoscopic resection rather than traditional surgery. However, there is still no complete consensus on the risk factors for lymph node metastasis (LNM) and recurrence of ESCC after endoscopic resection. The existing curative resection criteria are strict to a certain extent, and a considerable number of patients are overtreated according to the current standard of additional treatment. Thus, we aim to conduct a multi-center retrospective and prospective study to construct a large cohort of ESCC based on the previously established multi-center collaborative research network and clinical big data, analyze the risk factors of LNM and recurrence in patients with early esophageal squamous cell carcinoma after ESD, establish an accurate and simple risk prediction model, and evaluate the discrimination efficiency of this model.
Eligibility criteria
Qualifiers
Men and women, aged 18-85.
ESD was performed for early (superficial) esophageal squamous cell carcinoma, and the indication was in line with domestic and foreign guidelines.
The pathological stage after ESD was pT1a/pT1b.
The effective follow-up time after ESD was ≥3 years, or recurrence or LNM occurred during the follow-up period.
Disqualifiers
Esophageal chemoradiotherapy or esophageal surgery were performed before ESD.
There is a history of carcinoma, early carcinoma, adenoma and other benign and malignant tumors of stomach and duodenum.
Pathological data after ESD were incomplete.
Combined with malignant tumors of other organs.
Trial design
Treatments tested in this trial
- observational study
Treatment groups
No treatment groups listed
Sponsors and collaborators
Changhai Hospital
Lead sponsor
Lianshui People's Hospital
Collaborator
The second affiliated hospital of Xuzhou medical university
Collaborator
The second people's hospital of Nanyang
Collaborator
Nanchong Central Hospital
Collaborator
Tongliao City Hospital
Collaborator
Yancheng First People's Hospital
Collaborator
The Second Hospital of Hebei Medical University
Collaborator
The Second Affiliated Hospital of Baotou Medical College
Collaborator
Affiliated Hospital of Southwest Medical University
Collaborator
Sichuan Cancer Hospital and Research Institute
Collaborator
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Collaborator
Zhongda Hospital
Collaborator
The First Affiliated Hospital with Nanjing Medical University
Collaborator
West China Hospital
Collaborator
The First Affiliated Hospital of Soochow University
Collaborator
Jiangsu Province Hospital of Traditional Chinese Medicine
Collaborator
Shandong Provincial Hospital
Collaborator
Shanxi Provincial People's Hospital
Collaborator
Henan Provincial People's Hospital
Collaborator
Anyang Cancer Hospital
Collaborator
Source ClinicalTrials.gov