Chronic Heart Failure - COngestion eValuation

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorPr. Nicolas GIRERD

About this trial

Heart failure (HF) is a significant cause of death and the leading cause of hospitalization in patients over 65 years of age. Congestion is the main source of symptoms and the leading cause of hospitalization for HF. Furthermore, congestive signs identified in asymptomatic patients are associated with the risk of developing symptomatic HF. The literature supports a multi-modality / integrative evaluation of congestion, combining clinical examination, laboratory results and ultrasound evaluation.

The main objective of the CHF-COV study is to identify congestion markers (clinical, biological and ultrasound) quantified during a consultation or day hospitalization for the monitoring of chronic HF that are associated with the risk of all-cause death or hospitalization for acute HF within 24 months after day hospitalization.

Eligibility criteria

Qualifiers

Patients with chronic acute heart failure admitted in hospital for scheduled day hospitalization or consultation

Age ≥18 years

Patients having received complete information regarding the study design and having signed their informed consent form.

Patient affiliated to or beneficiary of a social security scheme.

Disqualifiers

Comorbidity for which the life expectancy is ≤ 3 months

Dialysis patient (peritoneal dialysis or hemodialysis) or patients with glomerular filtration rate <15 ml/min/m2 at inclusion.

History of lobectomy or pneumonectomy lung surgery

Severe pulmonary or pleural pathology preventing reliable acquisition of lung ultrasound images: severe emphysema, chronic pleurisy, pulmonary fibrosis, etc.

Trial design

Treatments tested in this trial

  • Clinical examination centered on congestion
  • Cardiac, pulmonary, peritoneal, jugular, renal Doppler ultrasounds and liver elastography
  • Blood sample retrieved for biological assessment and biobanking
  • Telephone follow-up
  • Kansas City Cardiomyopathy Questionnaire (KCCQ)

Treatment groups

200 Participants
are divided into 1 treatment group

Sponsors and collaborators

Pr. Nicolas GIRERD

Lead sponsor

Central Hospital, Nancy, France

Sponsor institution