Chronic Heart Failure With Preserved Ejection Fraction - COngestion eValuation

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorCentral Hospital, Nancy, France

About this trial

Heart failure (HF) is a significant cause of death and the leading cause of hospitalization in patients over 65 years of age. Congestion is the main source of symptoms and the leading cause of hospitalization for HF. Furthermore, congestive signs identified in asymptomatic patients are associated with the risk of developing symptomatic HF. The literature supports a multi-modality / integrative evaluation of congestion, combining clinical examination, laboratory results and ultrasound evaluation.

The main objective of the CHF-COV Preserved study is to identify congestion markers (clinical, biological and ultrasound) quantified during a consultation or day hospitalization for the monitoring of chronic HF with preserved left ventricular ejection fraction that are associated with the risk of all-cause death, hospitalization for acute HF or IV diuretics injection in a day hospital.

Eligibility criteria

Qualifiers

Patients with chronic acute heart failure with preserved ejection fraction admitted in hospital for scheduled day hospitalization or consultation

Patient with preserved left ventricular ejection fraction (≥50%).

Age ≥18 years

Patients having received complete information regarding the study design and having signed their informed consent form.

Disqualifiers

Comorbidity for which the life expectancy is ≤ 3 months

Dialysis patient (peritoneal dialysis or hemodialysis) or patients with glomerular filtration rate <15 ml/min/m2 at inclusion.

History of lobectomy or pneumonectomy lung surgery

Severe pulmonary or pleural pathology preventing reliable acquisition of lung ultrasound images: severe emphysema, chronic pleurisy, pulmonary fibrosis, etc.

Trial design

Treatments tested in this trial

  • Clinical examination centered on congestion
  • Cardiac, pulmonary, peritoneal, jugular and renal Doppler ultrasounds and liver elastography
  • Blood and urine sample retrieved for biological assessment and biobanking
  • Telephone follow-up
  • Kansas City Cardiomyopathy Questionnaire (KCCQ)

Treatment groups

200 Participants
are divided into 1 treatment group