Chronic Ingestion of Fructooligosaccharide and Psyllium on Intestinal Transit in Women With Functional Constipation: A Randomized Crossover Trial

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-59
SponsorFederal University of Minas Gerais

About this trial

The goal of this clinical trial is to evaluate the effect of dietary fibers in the treatment of functional constipation in women. It will also assess the potential side effects associated with fiber consumption. The main questions it aims to answer are:

* In women with constipation who do not consume adequate dietary fiber, does supplementation help improve bowel function? * Among the fibers studied, is there any hierarchy of effect in the treatment of constipation (i.e., is one more effective than the other)?

The researchers will compare the effects of the two dietary fibers against each other and against a control to evaluate their impact.

Participants will:

* Consume 20 g of fiber daily for 6 days, divided into two doses of 10 g each. * Attend a nuclear medicine visit at the end of each 6-day fiber period to perform scintigraphy. * Keep a daily record of bowel habits and dietary intake.

Eligibility criteria

Qualifiers

Female participants aged 18-59 years.

Willingness to sign the Informed Consent Form .

No restrictions on the consumption of egg or gluten.

No history or diagnosis of gastrointestinal diseases other than functional constipation.

Disqualifiers

Diagnosis of diabetes, severe hyperthyroidism, or hypothyroidism.

Use of opioid medications.

Delayed gastric emptying at 4 hours during the placebo period (participants meeting this criterion will be excluded from final analysis).

Trial design

Treatments tested in this trial

  • Psyllium powder
  • Fructooligosaccharide

Treatment groups

25 Participants
are divided into 2 treatment groups

Sponsors and collaborators