Chronic Nausea and Vomiting in Patients With Normal Gastric Emptying Using the Enterra® Therapy System (NAVIGATE)

ConditionsNauseaVomiting
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorEnterra Medical, Inc.

About this trial

The purpose of this research study is to determine if the Enterra® Therapy System can decrease nausea and vomiting symptoms and improve the quality of life for patients with chronic nausea, with or without vomiting, that have normal gastric emptying.

Eligibility criteria

Qualifiers

Willing and able to complete the informed consent process

Stated willingness to comply with all study procedures and availability for the duration of the study

Aged ≥18 years at time of informed consent

Chronic, drug-refractory nausea that: a) has been present for more than 6 months, and b) has been active within the last 3 months prior to consent

Disqualifiers

Cognitive impairment or other characteristic that would limit a patient's ability to complete study requirements

Pyloric transection therapy completed within 1 year of consent

Documented gastrointestinal (GI) obstruction or pseudo-obstruction

History of primary swallowing disorders

Trial design

Treatments tested in this trial

  • Enterra Therapy System

Treatment groups

148 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Enterra Medical, Inc.

Lead sponsor

Bright Research Partners

Collaborator