CHronic Nonbacterial Osteomyelitis International Registry
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeUp to 21
SponsorSeattle Children's Hospital
About this trial
The objective of the study is to establish a prospective disease registry for chronic recurrent multifocal osteomyelitis (CRMO)/chronic nonbacterial osteomyelitis (CNO) in order to investigate the natural history of the disease and the responses of patients to different clinical managements over 10 years.
Eligibility criteria
Qualifiers
- Age at enrollment is equal to or younger than 21 years of age
Presence of bone edema on STIR or T2 fat saturation sequence on MRI within 12 weeks of enrollment
Whole body imaging evaluation (either WB MRI or bone scintigraphy)
Bone biopsy to exclude infection or malignancy unless bone lesions follow typical distribution or there is IBD, psoriasis, or palmar plantar pustulosis
Disqualifiers
- History of or current malignancy
Current infectious osteomyelitis
Contraindication to the selected treatment agent
Trial design
Treatments tested in this trial
- Methotrexate
- Sulfasalazine
- Leflunomide
- Pamidronate
- Zoledronic acid
- Etanercept
- Adalimumab
- Certolizumab
- Infliximab
- Golimumab
- NSAID
Treatment groups
2,000 Participants
are divided into 4 treatment groupsSponsors and collaborators
Seattle Children's Hospital
Lead sponsor
Boston Children's Hospital, Boston, MA, USA
Collaborator
Hospital for Special Surgery, New York
Collaborator
Joseph M Sanzari Children's Hospital, Hackensack University Medical Center, Hackensack, NJ, USA
Collaborator
Riley Children's Hospital, Indianapolis, IN, USA
Collaborator
University of North Carolina, Chapel Hill, NC, USA
Collaborator
Royal Children's Hospital
Collaborator
Hacettepe University
Collaborator
Bambino Gesù Children's Hospital, Rome, Italy
Collaborator
University of British Columbia, Vancouver, BC, Canada
Collaborator
Meyer Children's Hospital, Florence, Italy
Collaborator
Mansoura University
Collaborator
University of Utah, Salt Lake City, UT, USA
Collaborator
University of Iowa Carver College of Medicine, Iowa City, IA, USA
Collaborator
Ann & Robert H Lurie Children's Hospital of Chicago
Collaborator
Palacky University Olomouc Institute of Molecular and Translational Medicine, Olomouc, Czechia
Collaborator
Alder Hey Children's NHS Foundation Trust
Collaborator
University of Calgary
Collaborator
Source ClinicalTrials.gov