Chrono-behavioral Therapy for Chronic Fatigue in Cancer
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAarhus University Hospital
About this trial
Cancer-related fatigue (CRF) is a severe and persistent side effect of cancer and its treatment, affecting up to 40% of patients and significantly reducing quality of life. Recent research suggests that circadian rhythm disruption has been implicated as a possible related pathophysiological mechanism underlying CRF. Circadian rhythms are 24-hour cycles regulating physiology and behavior through environmental cues called "zeitgebers." Strengthening these cues-such as light exposure, physical activity, and eating-may help reduce CRF.
This project will develop and test the optimal combination a home-based, low-burden chrono-behavioral therapy (ChronoBT) targeting these zeitgebers.
Eligibility criteria
Qualifiers
prostate or female breast cancer survivors
completed local and/or adjuvant cancer therapy (with the exception of hormonal therapy) ≥ 1 year previously
≥18 years of age
able to speak and read Danish
Disqualifiers
use of light therapy in the last year
confounding underlying medical/psychiatric disorders or use of medications associated with fatigue (e.g., a central nervous system cancer, untreated hypothyroidism, anemia, chronic fatigue syndrome, insomnia, major depression)
non-cancer related factor likely to be a driver of fatigue (e.g., shift work, pregnancy, recent travel across time zones)
recurrence of cancer or new cancer
Trial design
Treatments tested in this trial
- Chronotherapy
- Control
Treatment groups
200 Participants
are divided into 8 treatment groups8
Treatment groupsSee each treatment group below.
Sponsors and collaborators
Aarhus University Hospital
Lead sponsor
University of Aarhus
Sponsor institution
University of Aarhus
Collaborator
Source ClinicalTrials.gov