Circuitry-Guided Smoking Cessation in Schizophrenia (UH3)
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age22-65
SponsorThe University of Texas Health Science Center, Houston
About this trial
Patients with schizophrenia spectrum disorder (SSD) will be exposed to active repetitive transcranial magnetic stimulation (rTMS) from F8 coil or active rTMS from H coil for smoking cessation. Smoking and brain functional connectivity changes will be assessed at baseline, different stages of rTMS and/or follow-ups.
Eligibility criteria
Qualifiers
Male and female between ages 22-65 years
Ability to give written informed consent
Smoking in the last one year or more and average cigarette per day ≥ 5 in the past 4 weeks
Diagnosed with schizophrenia-spectrum disorder and Evaluation to Sign Consent (ESC) above10.
Disqualifiers
Persons with a first-degree relative with inherited epilepsy, seizure disorder, or seizures or persons who answer "yes" to any of the parts (A. - G.) of Question 3 of an epilepsy screening questionnaire.
Had smoking cessation treatment, clinical trial, or nicotine replacements within the past four weeks.
Significant alcohol or other drug use (substance dependence within 6 months or substance abuse within 1 month) other than nicotine or marijuana dependence.
Any major medical illnesses that may affect normal brain functioning. Examples of these conditions include, but not limited to, stroke, CNS infection or tumor, other significant brain neurological conditions.
Trial design
Treatments tested in this trial
- active F8-coil delivered rTMS
- active H-coil delivered rTMS
Treatment groups
50 Participants
are divided into 2 treatment groupsSponsors and collaborators
The University of Texas Health Science Center, Houston
Lead sponsor
National Institute on Drug Abuse (NIDA)
Collaborator
Source ClinicalTrials.gov