The main aim of the present study is to evaluate the effectiveness of two dietary protocols: Daily Caloric Restriction (DCR) and Early Time-Restricted Feeding + DCR (eTRE) on metabolic homeostasis and the influence of circulating extracellular vesicles (EVs) as inter-organ communication elements in obese patients.
age between 18 and 70 years old.
BMI ranges between 27 and 40 kg/ m2.
Absence of underlying pathology in medical and physical examination, except for those related to excess weight.
Signature of the informed consent for participation in the study.
Serious systemic disease not related to obesity, such as cancer, kidney or severe liver disease.
Systemic diseases with intrinsic inflammatory activity (autoimmune diseases such as rheumatoid arthritis and asthma).
Pregnancy and lactation.
Vegetarians or subjects subjected to an irregular diet.