Circulating Non-coding RNA in Acute Ischemic Stroke With Endovascular Treatment (EVTRNA)
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-90
SponsorNanjing First Hospital, Nanjing Medical University
About this trial
EVTRNA is to analyze the differentiated expression pattern of circular RNA (circRNA), long non-coding RNA (lncRNA) and micro-RNA (miRNA) by next-generation sequencing in acute ischemic stroke patients before and/or after endovascular treatment. The candidate circRNA/lncRNA/miRNA will be verified as the biomarker and regulator for progression and prognosis of acute ischemic stroke with endovascular treatment. Further, the candidate non-coding RNA will be used to evaluate the effect of endovascular treatment on both peripheral and central immune after stroke.
Eligibility criteria
Qualifiers
Aged 18 years or older
Confirmed acute ischemic stroke by a diffusion-weighted imaging-position lesion on magnetic resonance imaging (MRI) and a new lesion on a brain computed tomography (CT) scan
Within 24 hours of symptom onset and treat with endovascular therapy
Good performance status
Disqualifiers
a history of hemorrhagic infarction, chronic kidney/liver diseases, peripheral arterial occlusive disease, active malignant disease, and inflammatory or infectious diseases
Trial design
Treatments tested in this trial
- Sequencing of circRNA/lncRNA/miRNA
Treatment groups
300 Participants
are divided into 2 treatment groupsSponsors and collaborators
Nanjing First Hospital, Nanjing Medical University
Lead sponsor
Zhongda Hospital
Collaborator
Source ClinicalTrials.gov