Clinical Application Study of PET/CT for Differential Diagnosis of Non-small Cell Lung Cancer
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorRenJi Hospital
About this trial
This study aims to explore the efficacy of Trop2, EpCAM-specific PET/CT imaging for noninvasive visualization of Trop2 or EpCAM expression levels in non-small cell lung cancer; and to explore the differences between novel target-specific PET/CT examinations and conventional 18F-FDG PET/CT in the diagnosis and differential diagnosis of solid lung nodules.
Eligibility criteria
Qualifiers
Age 18-80 years;
Imaging studies suspecting non-small cell lung cancer;
Solid lung nodules (≥8 mm in diameter) diagnosed by chest ct, which are subject to 18F-FDG PET/CT and surgical resection/biopsy of lung nodules according to the NCCN guideline specifications for NSCLC in the 2024 edition;
Patients or family members agreed to participate in this clinical study and signed an informed consent form.
Disqualifiers
Women during pregnancy and lactation;
Persons with a history of surgery and trauma that significantly affects metabolic distribution and anatomical structure;
Persons with severe other systemic diseases or known hypersensitivity to humanized monoclonal antibody products;
Patient is unable to cooperate in completing the PET/CT examination;
Trial design
Treatments tested in this trial
- [68Ga]Ga-NOTA-T4
- [68Ga]Ga-NOTA-RT4
- [18F]F-RESCA-T4
- [18F]F-RESCA-RT4
- [18F]F-RESCA-EPCD6
- [68Ga]Ga-NOTA-EPCD6
Treatment groups
100 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov