Clinical Efficacy and Mechanism of tDCS for Dysphagia in PD
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-100
SponsorWang Ping
About this trial
This study aims to verify transcranial direct current stimulation(tDCS) efficacy for Parkinson's disease (PD)-related dysphagia and its mechanism. Subjects are randomly split into two groups: control (sham tDCS + conventional dysphagia treatment) and experimental (real tDCS + conventional treatment).
Assessments will be conducted at baseline, after the completion of intervention, and at the 3-month follow-up. Swallowing function will be evaluated via gold-standard videofluoroscopic swallowing study (VFSS) and scales. Resting-state functional magnetic resonance imaging (rs-fMRI) or functional near-infrared spectroscopy (fNIRS) will be measures for tracking changes in abnormal brain regions/networks.
Correlations between swallowing recovery and brain function changes, plus group imaging differences, will reveal tDCS's neurophysiological mechanism.
Eligibility criteria
Qualifiers
Meet the Chinese Diagnostic Criteria for Parkinson's Disease (2016) or MDS Diagnostic Criteria for Multiple System Atrophy or Progressive Supranuclear Palsy;
VFSS examination indicates dysphagia;
Mini-Mental State Examination (MMSE) score >23;
Willing to cooperate with the study and sign the informed consent form;
Disqualifiers
Comorbid with other diseases that cause dysphagia;
Comorbid with pneumonia, or severe cardiac/renal insufficiency;
Having metal implants in the body
With cognitive impairment or inability to cooperate.
Trial design
Treatments tested in this trial
- tDCS
- Conventional Dysphagia Treatment
- sham tDCS
Treatment groups
58 Participants
are divided into 2 treatment groupsSponsors and collaborators
Wang Ping
Lead sponsor
Second Affiliated Hospital, School of Medicine, Zhejiang University
Sponsor institution
Source ClinicalTrials.gov