Clinical Efficacy of Transarterial Infusion Chemotherapy for Unresectable Colorectal Cancer
ConditionUnresectable Colorectal Cancer
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorQuanda Liu
About this trial
This is a prospective, multicenter, randomized, and open-label clinical trial. It is initiated to determine the efficacy of FOLFOX-based, transarterial infusion chemotherapy (TAIC) combined with either cetuximab or bevacizumab for patients with unresectable colorectal cancer (CRC).
Eligibility criteria
Qualifiers
Age ≥ 18 years;
Colorectal cancer confirmed by CT/MRI and colonoscopic biopsy；
Patients unfit for surgery due to poor general condition or tumor extent and location;
Patients who have not received prior chemotherapy or those who have undergone prior chemotherapy but remain chemosensitive.
Disqualifiers
Patients with other primary malignant tumors;
Patients with gastrointestinal perforation;
Patients are allergic to the antitumor agents;
Women who are pregnant, breastfeeding, or planning to become pregnant;
Trial design
Treatments tested in this trial
- Transarterial infusion chemotherapy (TAIC)
- Intravenous Chemotherapy（IVC）
Treatment groups
30 Participants
are divided into 2 treatment groupsLocations
1Map coordinates are unavailable for these locations. Locations are shown below instead.
Guang'anmen Hospital, China Academy of Chinese Medical SciencesRecruiting100053, Xicheng, Beijing Municipality
China
ChinaSponsors and collaborators
Quanda Liu
Lead sponsor
Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Sponsor institution
Liaoning Cancer Hospital & Institute
Collaborator
The Rocket Force Characteristic Medical Center
Collaborator
Second Affiliated Hospital of Nanchang University
Collaborator
Affiliated Hospital of Hebei University
Collaborator
The First Hospital of Qinhuangdao
Collaborator
The Central Hospital of Handan City
Collaborator
The First People's Hospital of Jiujiang City
Collaborator
Changzhi Medical College
Collaborator
Zibo Boshan District Traditional Chinese Medicine Hospital
Collaborator
Linshu County People's Hospital
Collaborator
Hebei Yixian Hospital
Collaborator
Baoding Mancheng District People's Hospital
Collaborator
Source ClinicalTrials.gov