Clinical Efficacy of Transarterial Infusion Chemotherapy for Unresectable Colorectal Cancer

ORR

ORR is defined as the percentage of complete response and partial response that is maintained for at least 4 weeks from the first radiological confirmation.

Health-related quality of life

Health-related quality of life was assessed using the European Organization for Research and Treatment of Cancer (EORTC) 30-item QoL Questionnaire (EORTC QLQ-C30). The EORTC QLQ-C30 consists of 30 items covering five functioning scales (physical, social, emotional, role, and cognitive), nine symptom scales (fatigue, nausea/vomiting, pain, dyspnea, sleep disturbances, appetite loss, constipation, diarrhea, and financial impact), and a global health status scale. Referring to a recall period of one-week (except for physical function, which does not refer to a recall period at all), patients indicate their answers on a 4-point Likert scale. Linear converted scale scores range from 0 to 100. Higher scores on the functioning scales and on the global health status scale indicate better functioning, whereas higher scores on the symptom scales indicate greater symptom burden.

Clinical complete response

Clinical complete response is defined as no visible tumor on imaging examination.

The rate of conversion to resectable status

The assessment of surgical resectability by an experienced and dedicated multidisciplinary team is required at each tumor assessment.

Pathological complete response

The pathological complete response is defined as the absence of invasive neoplastic cells upon microscopic examination of the primary tumor during surgery.

Adverse events

Adverse events are defined that newly appeared, increased in frequency, or worsened in severity following initiation of study drug. Adverse events were graded according to National Cancer Institute Common Terminology Criteria for Adverse Events, version 6.0.