Clinical Pharmacology of Dexamethasone in Pregnant Women With Preterm Labor

ConditionsRespiratory Distress Syndrome of Newborn Threatened Premature Labor, Antepartum

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexFemale

Age20-40

SponsorDongyang Liu

About this trial

This study through to the pregnant woman blood concentrations of dexamethasone therapy after research, explore the pharmacokinetic data of dexamethasone in pregnant women, Chinese pregnant women dexamethasone pharmacokinetic model, provide a reference for the clinical use of dexamethasone dose, through the biomarkers of dexamethasone to promote fetal lung maturity and other metabolomics, It provides the basis for the effectiveness and safety study of dexamethasone.

Eligibility criteria

Qualifiers

Aged 20-40 (inclusive);

Body mass Index (BMI) 18.5-27.9kg /m2 (inclusive)

Single and twin pregnancy;

Premature delivery at 24-36 weeks;

Disqualifiers

Ectopic pregnancy;

Suffering from diabetes, fetal distress, serious infectious diseases (such as sepsis, septic shock), fever;

Those who have taken glucocorticoid drugs within 2 weeks before joining the clinical trial;

Those who took clindamycin during the study period;

Trial design

Treatments tested in this trial

Not listed

Trial groups

288 Participants

are grouped into 8 trial groups

Trial groups

See each trial group below.

Sponsors and collaborators

Dongyang Liu

Lead sponsor

Peking University Third Hospital

Sponsor institution

Source ClinicalTrials.gov