Clinical Research on Moderately Hypofractionated Adaptive Postoperative Radiotherapy for High-Risk Endometrial Cancer
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-70
SponsorXiaorong Hou
About this trial
1. Study Type: Single-center, single-arm, prospective study. 2. Sample Size: 20 patients with high-risk endometrial cancer were enrolled. 3. Treatment Procedure:
The existing clinical oART (Online Adaptive Radiotherapy) workflow protocol for malignant tumors used in our department was applied.
Procedures included simulation, target volume delineation, radiotherapy planning, and treatment delivery.
External beam radiation therapy (EBRT) was delivered using moderate hypofractionation.
If indicated, brachytherapy was performed after the completion of EBRT. When combined with chemotherapy, radiotherapy could be administered during chemotherapy intervals or after completion of chemotherapy. 4. Study Endpoints:
Primary Endpoint: Incidence of acute toxicity. Secondary Endpoints: 3-year failure-free survival (FFS) rate, incidence of chronic toxicity, quality of life (QoL), treatment costs, etc.
Eligibility criteria
Qualifiers
Age : 18-70 years old.
Expected to comply with oART (Online Adaptive Radiotherapy) workflow.
Patients and families fully understand the study protocol.
Voluntarily participate and sign informed consent forms before enrollment
Disqualifiers
Prior Radiotherapy : History of abdominal or pelvic irradiation.
Malignancy History : Prior diagnosis of other malignancies.
Pregnancy/Lactation : Pregnant or breastfeeding women.
Active Infection : Fever or uncontrolled active infection.
Trial design
Treatments tested in this trial
- Moderately Hypofractionated Adaptive Radiotherapy
Treatment groups
20 Participants
are divided into 1 treatment groupSponsors and collaborators
Xiaorong Hou
Lead sponsor
Peking Union Medical College Hospital
Sponsor institution
Source ClinicalTrials.gov