Clinical Study on the Efficacy of Single-port Inflatable Mediastinoscopy Combined With Laparoscopic-assisted Small Incision Surgery and Thoracoscopy Combined With Laparoscopic Surgery for Radical Esophagectomy

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-75
SponsorFifth Affiliated Hospital, Sun Yat-Sen University

About this trial

We previously developed a novel non-trans thoracic esophagectomy, the single-port inflatable mediastinoscopy combined with laparoscopy for the radical esophagectomy of esophageal cancer.This study is evaluating the feasibility and safety of radical resection of single-port inflatable mediastinal mirror synchronization with laparoscopic esophageal carcinoma, as well as the clinical value of the radical resection of single-port inflatable mediastinal mirror synchronization with laparoscopic esophageal carcinoma as a new minimally invasive operation for esophageal carcinoma.

Eligibility criteria

Qualifiers

18 years old ≤ age ≤ 75 years old, no gender limit;

Patients who are diagnosed as esophageal malignant tumor by cytology or histology, and agree to undergo surgical treatment;

The preoperative clinical tumor staging is T1-2N0-1M0 patients; or T3N1-2M0 patients undergo neoadjuvant treatment (neoadjuvant chemotherapy, neoadjuvant chemoradiation, neoadjuvant radiotherapy, neoadjuvant chemotherapy and immunotherapy, neoadjuvant radiotherapy and immunotherapy After treatment), assess the tumor to achieve partial response (PR) and surgical resection is feasible;

The tumor is located in the thoracic esophagus;

Disqualifiers

People who suffer from other malignant tumors at the same time;

Patients with a history of esophagus or gastrectomy;

Patients with a history of mediastinal surgery or extensive abdominal cavity adhesion;

Patients with basic diseases such as cardiovascular and cerebrovascular diseases;

Trial design

Treatments tested in this trial

  • Single-Port Inflatable Mediastinoscopy Combined With Laparoscopic-Assisted Small Incision Surgery
  • Thoracoscopy Combined With Laparoscopic Surgery

Treatment groups

1,164 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Fifth Affiliated Hospital, Sun Yat-Sen University

Lead sponsor

General Hospital of Ningxia Medical University

Collaborator

Beijing Chao Yang Hospital

Collaborator

West China Hospital

Collaborator

Shanghai Chest Hospital

Collaborator

Peking University Cancer Hospital & Institute

Collaborator

The First Affiliated Hospital of Nanchang University

Collaborator

Changzhi Medical College

Collaborator

Zhangzhou Affiliated Hospital of Fujian Medical University

Collaborator

Harbin Medical University

Collaborator

Hubei Cancer Hospital

Collaborator

Jining First People's Hospital

Collaborator

Jiangsu Cancer Institute & Hospital

Collaborator

Nanfang Hospital, Southern Medical University

Collaborator