Clinical Study on the Re-irradiation of Lateral Pelvic Recurrences of Gynecological Malignancies

ConditionsTumor Recurrence Malignant Epithelial Neoplasm of Vulva Malignant Epithelial Tumor of Ovary Malignant Epithelial Neoplasm

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexFemale

Age18+

SponsorCNAO National Center of Oncological Hadrontherapy

About this trial

The study aims to obtain a local control rate in patients with lateral pelvic relapses of gynecologycal cancers previously irradiated. High LET (Linear Energy Transfer) particles as carbon ions can guarantee a biologic advantage compared to photons in radioresistant neoplasms, given to their higher biological efficacy (RBE).

Eligibility criteria

Qualifiers

Patients ≥ 18 years of age

Karnofsky Index ≥ 70

Histological or radiological diagnosis of pelvic and groin recurrence

Contraindications for radical surgery

Disqualifiers

Hip prosthesis, metal prostheses or any other condition that prevents adequate imaging to identify the target volume and calculate the dose in the treatment plan

Intestinal infiltration

Bladder infiltration

Vessel infiltration

Trial design

Treatments tested in this trial

carbon ion radiation therapy

Treatment groups

55 Participants

are divided into 1 treatment group

Sponsors and collaborators

CNAO National Center of Oncological Hadrontherapy

Lead sponsor

Source ClinicalTrials.gov