Multi-center observational study to evaluate the histopathology and transcriptome of cutaneous lesions in patients with several different types of vasculitis.
Have a cutaneous lesion (purpuric macules, palpable purpura, retiform purpura, nodules, ulcers, or urticarial) believed to be related to active vasculitis
Cryoglobulinemic vasculitis (CV)
Drug-induced vasculitis
Eosinophilic granulomatosis with polyangiitis (EGPA)
You are less than five years old
Considered not to be a candidate for a biopsy or have a higher risk of developing an infection, bleeding, etc., from the biopsy, or a doctor believes that the risks for you participating in this study do not outweigh the potential benefit of learning information from your biopsy
You have a neutrophil count (type of white blood cell) less than 1500/mm3, platelet count less than 50,000/mm3, or a hemoglobin less than 7 g/dL
You have an uncontrolled disease that could prevent you from completing the study procedures
Peter Merkel
Lead sponsor
University of Pennsylvania
Sponsor institution
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Collaborator
National Center for Advancing Translational Sciences (NCATS)
Collaborator
Office of Rare Diseases Research (ORDR)
Collaborator