The goal of this clinical trial is to evaluate safety and efficacy of percutaneous peripheral nerve stimulation in patients with peripheral neuropathic pain. The main questions it aims to answer are:
1. The efficacy of percutaneous peripheral nerve stimulation in patients with peripheral neuropathic pain 2. The safety of percutaneous peripheral nerve stimulation in patients with peripheral neuropathic pain Participants are going to undergo procedure that implant peripheral nerve stimulation electrode produced by Jiangsu CED Medtech Co., Ltd. Then the subjects, whose VAS scores decrease more 30% than baseline level, are classified into two groups randomly. One of the group receiving active stimulation called trial group and another receiving placebo stimulation called control group. All subjects are required to make their own subjects' pain diary to record VSA score before and after implantation until at the end of follow-up. Also, participants are asked to report use of analgesic medications, number of awakenings and adverse events.
Researchers will compare pain scores between the two groups to see if peripheral nerve stimulation is effective to patients with peripheral neuropathic pain.
18 years old and above, male or female
Diagnosed by trained clinical doctors as postherpetic neuralgia, which is an indication for peripheral nerve stimulation therapy;
Assess the damage or disease of the peripheral sensory system through the four questions of Douleur Neuropathy before surgery;
The subject has received conventional treatment but the efficacy is poor, or cannot tolerate the side effects of conventional treatment;
Subjects who need to receive both radio frequency modulation and intrathecal drug infusion treatment simultaneously;
Subjects who are known to have cardiac implants (pacemakers or defibrillators) or other implantable neural stimulators (spinal cord stimulators or deep brain stimulators, etc.);
Subjects with severe psychological and/or mental disorders and/or non therapeutic drug dependence;
Subjects expected to undergo MRI examination within 30 days after PNS implantation;
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lead sponsor
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Collaborator
The Second People's Hospital of GuangDong Province
Collaborator
Xiamen Hospital of Traditional Chinese Medicine
Collaborator