Using specific EEG biomarkers in methamphetamine-dependent individuals, this study systematically probes closed-loop continuous Theta-burst Stimulation (cTBS) based on brain states, assessing dosage, neurologic and behavioral effects, while comparing its efficacy with traditional open-loop cTBS methods.
Individuals aged between 18 and 60 years, irrespective of gender, having completed a minimum of 9 years of education and capable of effectively cooperating in questionnaire evaluations.
Meet the diagnostic criteria set forth by the DSM-V concerning the amphetamine-type substance addiction.
A history of utilizing amphetamine-type substances for a duration not less than one year, with a frequency of use being at least once per week.
Consent to actively cooperate in the completion of subsequent follow-up assessments.
Severe cognitive functional impairments manifested through a history of head trauma, cerebrovascular diseases, epilepsy, etc., or usage of cognitive enhancement drugs in the past 6 months; an intellectual disability with an IQ score less than 70.
A diagnosis of schizophrenia or other severe mental illnesses as per the DSM-5 criteria.
Abuse or dependence on other psychoactive substances (excluding nicotine) within the past 5 years.
Severe organic diseases that might compromise study participation.