Closed-loop tES-non-invasive Stimulation
ConditionClosed-loop Brain Stimulation
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-40
SponsorUniversity of Nottingham
About this trial
The goal of this study is to establish if non-invasive closed-loop neuromodulation is an effective approach to enhance cognitive function in healthy 18-40 years old volunteers. The main questions it aims to answer are:
* Can closed-loop stimulation increase stimulation effectiveness? * Can closed-loop focused ultrasound specifically engage with excitatory or inhibitory neural populations in the target structure as measured through MRS? * Can observed stimulation outcomes for FUS be predicted through connectome analysis and computational models of indirect changes?
Researchers will compare different closed-loop options to their open-loop counterpart to see if closed-loop approaches can increase efficacy and reduce the variability of the stimulation compared to open-loop approaches.
Participants will:
* Answer some questionnaires at the start of the study and after each intervention session. * Undertake a MRI scanning session. * Undertake one open-loop FUS session. * Undertake one tES session. * Undertake one closed-loop FUS sessions involving tES and FUS, followed by a MRI scanning * Undertake one sham FUS session * Attend one visit in person to assess eligibility through questionnaires and one cognitive task
Eligibility criteria
Qualifiers
Participant is willing and able to give informed consent for participation in the study
Aged between 18 and 40
Good general health
Not consume alcohol 48 hours prior study visit
Disqualifiers
Inability to complete MRI/FUS/TMS/tES safety questionnaire and / or informed consent process.
Current or previous diagnosis of a neurological, neurosurgical, psychiatric disorders.
Other significant medical condition (specific details to be reviewed by the CI prior to inclusion).
Currently pregnant, breast feeding, or on planned pregnancy.
Trial design
Treatments tested in this trial
- Transcranial low intensity focused ultrasound (FUS)
- transcranial electrical stimulation
- Magnetic Resonance Imaging
Treatment groups
30 Participants
are divided into 4 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov