Closing the GAPS: Guideline Adherence, Prevention and Surveillance in Hereditary Cancer
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-49
SponsorNest Genomics
About this trial
The goal of this clinical trial is to see if a software platform can improve cancer screening in young adults with genetic risk for cancer.
The trial will also help improve the software platform (Nest). The main questions it aims to answer are:
* Do Nest users know more about their cancer risks and recommended care than non-users? * Do Nest users have less psychological distress than non-users? * Do Nest users share cancer risks with family and other doctors more than non-users? * Are Nest users more likely than non-users to have up-to-date care plans?
Researchers will compare Nest users to non-users to see if the Nest users are more likely to do recommended cancer screening.
Participants will:
* Have a genetic counseling or follow up visit * Take a post-visit survey * Intervention arm only: use the Nest Patient Navigator * Complete screening and follow-up care recommended by doctors
Eligibility criteria
Qualifiers
Ages 18-49 years, inclusive
previous cancer genetic testing with a finding of a pathogenic or likely pathogenic variant resulting in an increased risk of cancer warranting clinical management.
English-speaking and -reading
Receiving care at Dana Farber Cancer Institute
Disqualifiers
Age <18 or >49 years
Has not had genetic testing for hereditary cancer syndromes or has been tested but no pathogenic or likely pathogenic variant was identified.
Non-English speaking and reading
Not receiving care at Dana Farber Cancer Institute
Trial design
Treatments tested in this trial
- Nest, an electronic medical record (EMR)-integrated software platform to deliver longitudinal, genetics-based care at scale.
Treatment groups
100 Participants
are divided into 2 treatment groupsSponsors and collaborators
Nest Genomics
Lead sponsor
Dana-Farber Cancer Institute
Collaborator
National Human Genome Research Institute (NHGRI)
Collaborator
Source ClinicalTrials.gov